Federal government websites often end in. The site is secure. In recent years, the use of proton pump inhibitors PPI , especially omeprazole, has been associated with development of chronic kidney disease CKD. These drugs are widely used worldwide. This study aims to analyze the association between the continuous use of omeprazole and the progression of CKD in adult and elderly individuals.
A retrospective cohort study was conducted with patients followed up at a nephrology clinic in Brazil, in and Information about clinical and sociodemographic data, health behaviors, and medication use were collected from all patients diagnosed with CKD through consultation of medical charts and the Brazilian health information system SIS. The participants were allocated into two groups: users and non-users of omeprazole, and the progression of CKD was then evaluated for each group.
Multivariate analysis was performed using Cox regression. A total of CKD patients were attended in the polyclinic, and of these, There was a higher percentage of CKD progression in users The hazard ratio was 7.
An association between omeprazole use and progression of CKD stage was identified, showing a higher risk of disease evolution among omeprazole users. Chronic kidney disease CKD , characterized by progressive deterioration of biochemical and physiological functions of the body systems, can be defined as a syndrome caused by the progressive decrease in renal function [ 1 — 4 ].
Because of the changes in life expectancy that have made the elderly become the dominant group in populations worldwide, the epidemiological figures of CKD are increasing continually, placing renal diseases in the epidemic category.
